Publications

You can also find my articles on my Google Scholar profile.

2026

ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model

Published in Molecular Psychiatry

2025

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

Published in Nature Communications

Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain

Published in iScience

Endothelial cell Nrf2 controls neuroinflammation following a systemic insult

Published in iScience

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes

Published in Glia

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

Published in Nature Neuroscience

2024

A comparison of basal and activity-dependent exon splicing in cortical-patterned neurons of human and mouse origin

Published in Frontiers in Molecular Neuroscience

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation

Published in Neuropathology and Applied Neurobiology

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

Published in Molecular Autism

Laboratory Automated Interrogation of Data: an interactive web application for visualization of multilevel data from biological experiments

Published in Brain Communications

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

Published in Acta Neuropathalogica

2023

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease

Published in eLife

Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment

Published in Glia

General Anesthesia Alters CNS and Astrocyte Expression of Activity-Dependent And Activity-Independent

Published in Frontiers in Network Physiology

Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts

Published in Brain

Differential splicing choices made by neurons and astrocytes and their importance when investigating signal-dependent alternative splicing in neural cells

Published in Frontiers in Molecular Neuroscience

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Published in Nature Communications

Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion

Published in BMC Neuroscience

2022

Synaptic resilience is associated with maintained cognition during ageing

Published in Alzheimer’s & Dementia

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Published in Molecular Autism

Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3^-/y rat model of autism

Published in Molecular Autism

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

Published in Nature Communications

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Published in Nature Communications

2021

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

Published in Redox Biology

Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue

Published in Journal of Neurology, Neurosurgery & Psychiatry

Microarray profiling emphasizes transcriptomic differences between hippocampal in vivo tissue and in vitro cultures

Published in Brain Communications

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

Published in Cell Reports

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Published in Molecular Neurodegeneration

Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

Published in Cell Death & Disease

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

Published in Acta Neuropathologica

2020

Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells

Published in Stem Cell Research

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Published in Cell Reports

Neuronal Activity and Its Role in Controlling Antioxidant Genes

Published in International Journal of Molecular Sciences

Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function

Published in Human Molecular Genetics

2019

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology

Published in Glia

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Published in Cell Reports

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Published in Nature Communications

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

Published in Molecular Psychiatry

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

Published in Science Translational Medicine

2018

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Published in Molecular Psychiatry

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription

Published in Nature Protocols

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca²⁺-permeable AMPA receptor-mediated excitotoxicity

Published in Nature Communications

2017

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Published in Neuron

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Published in Nature Communications

2016

Characterisation of Cdkl5 transcript isoforms in rat

Published in Gene

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Published in eLife

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse

Published in PLOS ONE

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling

Published in PLOS ONE

2014

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

Published in The Journal of Physiology